The skin is the largest of the elimination channels. Through the skin toxins are eliminated which are brought to the skin surface from the blood. When the regular elimination channels are sluggish or partial plugged up such as your colon being constipated, not all toxins move out through your feces.
Toxins that accumulate in the colon tend to move into the blood, when colon walls have been weaken through constant constipation or abused through eating excessive junk food. Once
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